The Female (..and male) Sex Peptide
Increased libido, sexual desire, and arousal in women
Can treat hyperactive sexual desire disorder or erectyile dysfunction
Can help treat impotence in men
Can help treat premature ejaculation in men
Possible ant-inflammatory and anti-fungal actions
A subcutaneous injection is close to 100% bioavailable. The maximal effects occur approximately 1 HR after administration. 2 mg starting dose is typically recommended, 1 hr before sexual activity. The peptides half-life is 6-8 hrs. Typically it is recommended to use no more than 3x per week.
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PT-141, also called Bremelanotide, is a cyclic heptapeptide melanocortin originally developed from Melanotan 2 as a skin darkening agent, however, test subjects soon found it played a crucial role in sexual desire. It has been used to treat Erectile Dysfunction in men, and arousal conditions in women.
Mechanism of Action
PT-141 acts as a non-selective agonist of melanocortin receptors, primarily receptors 3 & 4, but not on receptor 2. PT-141 works through the nervous system instead of the cardiovascualar system, therefore is generally considered safe, even for those with cardiovascular conditions.
Diamond et al., 2004, invesigated the use of PT-141, Bremelanotide, for treatment of male erectile dysfunction (ED). They measured the erectile response of both healthy male subjects without visual sexual stimulation, and the response of Viagra-responsive ED patients with visual sexual stimulation. In both applications, PT-141 significantly increased erectile response compared to the placebo groups. The half-life of PT-141 ranged from 1.85 to 2.09 hours, while the maximum benefit was reached at 0.5 hours. At doses greater than 7 mg, erection peaks typically occured at approximately 0.5 hrs after administration. They furthermore found that PT-141 is well tolerated, and easy to administer. There were minimal side effects, some patients experienced flushing and nausea. They were not able to determine a maximum tolerated dose, meaning that PT-141 is considered fairly safe. Furthermore, they found no significant changes in pysiology (vitals, EKG scans, blood pressure, etc.).
Diamond, L., Earle, D., Rosen, R. et al. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res16, 51–59 (2004). https://doi.org/10.1038/sj.ijir.3901139
Female Sexual Disorders
There have been a few studies outlining the possible use of PT-141 for female arousal disorders. It has shown promising results in animal studies, including promoted arousal, initiation, and more. A study conducted by Clayton and Kingsberg, 2016, aimed to determine the effectiveness of PT-141 in premenopausal women when self-administered subcutaneously at-home on an an-desired basis for 12 weeks. The double blind study found PT-141 increased sexual desire and arousal, while decreasing distress. The effect dosing they found was between 1.25 and 1.75 mg, 0.75 mg had no effect.
In another study, 32 healthy female volunteers were treated with 0.3, 1.0, 3.0 or 5.0 mg of Bremelanotide, the results found a significant increase in arousal after treatments of the 3.0 and 5.0 mg doses.
An in-clinic study of 18 premenopausal women and 27 postmenupausal women with female sexual arousal disorder was conducted. On the premenopausal women it was reported that women who were treated with PT-141 vs placebo had much greater sexual arousal and desire, and any women who attempted sexual intercourse after the treatment reported much higher levels of satisfaction.
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