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The Anti-Anxiety Peptide
Dose
Injection SQ or IM: 250 mcg - 3 mg per day
Nasal Spray: 2-3 drops in each nasal passage 2-3 times per day
Nasal spray lasts for 90 days at room temperature, up to 24 months refrigerated.
Benefits
reduce anxiety
increase serotonin, with no risk of addiction
improve learning
enhance memory
increases BDNF (brain derived neurotrophic factor) an important brain growth compound that may help with brain damage
stabilizes enkephalins in the blood (counteract stress response)
help with withdrawal
prevent weight gain and reduce cholesterol.
stimulate IL-6 in the blood which is an anti-inflammatory protein that may help with infection
stimulate the release of interferons which are anti-viral molecules
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About
Selank was created at the Institute of Molecular Genetics along with V.V. Zakusov Research Institute of Pharmacology (or the Russian Academy of Medical Sciences). It was created from bonding the peptide Tuftsin with a sequence meant to improve its stability. Tuftsin is a naturally occurring peptide related to immune-function. Selank is currently approved for use in Russia for generalized anxiety disorder. In trials, Selank has provided sustained nootropic and anxiolytic effects.
Mechanism of Action
Selank induces the metabolism of serotonin. It also influences the concentration of monoamine neurotransmitters, e.g. Histamine, Adrenaline, Melatonin etc., which are involved in processes including mood, arousal, and memory. Selank modulates the expression of IL-6 (interleukin-6 protein) which is an anti-inflammatory myokine and a pro-inflammatory cytokine, and affects the balance of T helper cell cytokines. Selank inhibits enkephalin hydrolysis, an opioid neuro-pentapeptide involved in regulating nociiception in the body. Enkephalin is linked to brain function during stress. In all previous trials Selank shows no side effects or signs of withdrawal.
Side Effects
non-recognized
In Studies
Effect in expression of genes
Studies have found the physiological effects of Selank to be similar to benzodiazepines, such as diazepam and phenazepam. To further study this connection, a trial was designed to determine the effect of Selank and GABA on the expression of genes involved in neurotransmission. This study analyzed the expression of 84 genes involved in neurotransmission (including GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg). The results included significant positive changes in the expression of 45 genes 1 h after the administration of the compounds and change of expression of 22 genes 3 hours after administration. This study found that Selank has complex effects on nerve cells and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.
Immunotrophic and adaptogenic effects
A study conducted by Uchakina et Al. in 2008 revealed the immunotropic effects of the heptapeptide, selank. They found, in vitro study, that the drug in concentration of 10-7 M suppressed entirely gene expression by peripheral blood IL-6 of patients with depression while having no effect on the healthy controls. Further, after selank administration, they found a significant increase (p<0,05) of IL-6 concentration in the cell culture of the peripheral blood of patients. A group of patients studied were previously diagnosed with generalized anxiety disorder and neurasthenia, following 14 day administration of Selank, positive changes of the Th1/Th2 cytokine balance were observed. Additionally, positive cytokine regulating effects were revealed suggesting that selank has potential use as a novel immunomodulator in patients with anxiety-asthenic disorders, while the adaptogenic properties of selank may be beneficial in the prevention of infectious diseases in elderly people and people exposed to environmental stressors.
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