Updated: Apr 4, 2022
The Miracle Peptide
GHK-cu is a relatively small molecule allowing it to be absorbed readily through the skin (cosmetics)
GHK-cu is use subQ at 1-2 mg/day for periods of 30 days for advanced anti-aging, wound healing, liver protection, lung COPD
Special notes: as it is a copper peptide, GHK-Cu, when taken frequently, should be balanced with Zinc supplementation to avoid headaches and water retention.
Toxicity: GHK-cu is considered relatively safe and toxicity levels are much beyond a reachable level.
Reduces inflammation from free radical damage, reduces photodamage, repairs protective skin barrier proteins, improves overall skin appearance, smoothens rough skin, tightens loose skin, reverses appearance of aging, reduces fine lines, improves skin firmness, reduces the depth of wrinkles, stimulates healing of wounds and scars, protects the skin from harmful radiation.
Hair Regrowth Benefits
Increases hair growth and thickness. Increases circulation to the scalp. Improves hair transplant results. Enlarges hair follicle size. Block DHT in the scalp by obstructing the enzyme known as 5-alpha reductase (required to make DHT). Inhibit follicle death. Prolong the growth cycle of hair.
GHK-cu in combination with 625-635 nm LED irradiation increased basic fibroblast growth factor by 230% and collagen synthesis by 70%.
GHK-cu when used topically for 12 weeks reduced wrinkle volume by 55.8% and wrinkle depth by 32.8%
Stimulation of Blood Vessel and Nerve Growth, and Promotion of Nerve Outgrowth
wounds may be devoid of sensory abilities if inadequately healed, GHK-cu increases the production of neurotrophic factors.
Antioxidant and anti-inflammatory
reduce iron release from Ferritin by 87%, ferritin is a catalyst of lipid peroxidiation, a chain reaction that produces free radicals
Regeneration from Lung COPD and Acute Lung Injury: lung and connective tissue repair, suppresses infiltration of inflammatory cells into the lung. Lung fibroblasts that had impaired ability to contract and restructure collagen were repaired.
Blocking negative effects of Cortisone
topical cortisone can inhibit wound repair as well as produce skin thinning among other defects. Systematic GHK-cu has protective effects against cortisone.
Suppression of Fibrinogen
fibrinogen is known for its ability to form blood clots but also can greatly increase the viscosity of blood in microcirculation. A study with 5389 men over a 10-year period found that fibrinogen levels were a top contributing factor for cardiovascular disease. GHK Cu was found to have an inhibitory effect on the synthesis of fibrinogen
prevents damage to the liver, increased regeneration
Potent anti-cancer agent which down regulates the expression of metastatic genes. Suppresses RNA production in 70% of 54 overexpressed human genes in cancer patients. Resets gene activity in cancer patients back to health
Ubiquitin Proteasome System (UPS)
This system is a process by which the body clears damaged proteins. When it does not function properly damaged proteins start accumulating and aging is enhanced. Proteasome activation can slow down again. GHK-cu increases the activity of 41 genes in Ubiquitin System and decreased the activity of 1. Leaving a positive balance that aids with aging.
Anti-pain, Anti-anxiety, Anti-aggression
GHK cu was found to reduce pain at doses of 0.5 mg/kg. At this dose it was also found to reduce anxiety and fear. Furthermore, at this dose it was found to reduce aggression by 5-fold.
Psoriasis and Atopic Dermatitis
GHK-cu has analgesic and anxiolytic effects which lower anxiety and psychological stress and thereby have a positive effect chronic skin condition.
GHK-Cu was discovered in 1973 by Loren Pickhart. The human copper-binding peptide is a small and tripeptide. This naturally occurring peptide is present in human plasma. Since discovery it has been widely established as a protective and regenerative ingredient.
Mechanism of Action
GHK-Cu is a naturally occurring copper complex tripeptide. Originally thought mostly to be effective due to its ability to bind to copper, scientists have found its mechanism of action include its ability to modulate gene expression. Naturally, GHK-Cu is released by the body to aide in healing process of wounds. GHK-Cu can provide systematic healing: this means that when injected or absorbed into a localized area healing still occurs systematically throughout the body. It was discovered that, much similarly to HGH, the presence of GHK-Cu in the human body significantly decreases with age, where at age 20 it is present in body 200 ug/L, at 60 : 80ug/L.
For systematic healing and aging, gene expression and other studies regarding GHK-Cu have used subcutaneous injections of 1-2 mg per day for 20-30 days.
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