Epitalon (Epithalon)

The Fountain of Youth Peptide

Benefits

• Reverse the physical signs of aging

• restore and normalize melatonin production by pineal gland

• restore normal circadian rhythm of cortisol production

• prevention of cancer and age related diseases

• strong anti-oxidant properties

• significantly increase telomere length in blood cells

• inhibits the MMP9 protein in aging skin fibroblasts.

Dose

The recommended dose of Epitalon is 5-10 mg daily over 10-20 days, lower doses are typically given once per day and higher doses are split between morning and evening. Each course should be separated by 4-6 month break intervals.

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About

Epithalon was discovered by Professor Khavinson and approved for use in Russia in 1990. It has been used extensively in research in both humans and animals with no reported side effects. Epithalon is derived from the naturally occuring peptide, Epithalamin, which is produced in the pineal gland. Epithalon increases telomerase activity in somatic cells resulting in production of telomeres. Telomeres are located at the end of each chromosone and protect the chromosone from deterioration. Telomeres are shortened as a result of cell division, after many cell divisions the telomeres reach a critical length resulting in the cell losing the ability to further divide, and thus losing the ability to replace worn, damaged or diseased cells. At this point the cell has reached its Hayflick Limit, which is the number of times a cell will divide before cell division stops. The aging of cell populations and the length of telomeres strongly correlate with the physical aging of an organism. Telomerase is a ribonucleoprotein that adds telomere repeat sequence to the 3' end of telomeres and thereby elongating telomeres. Telomerase allows the cell line to divide without ever reaching the Hayflick Limit. Taking Epithalon stimulates the body to produce the telomerase activator peptide and has been found in studies of people over the age of 60 to increase telomere length.

Mechanism of Action

Epithalon is also known as the telomerase activator peptide which directly stimulates cells in the body to produce a telomerase enzyme. This enzyme renews and extends telomeres at the end of chromosones. This leads to the slowing of the aging of cell populations which directly effects the physical aging of a specimen. Epithalon has been used effectively in studies to reverse the physical signs of aging and age related diseases.

In Studies

Overcoming division limit in somatic cells

Khavinson et al., 2004, looked into the potential of Epithalon (Ala-Glu-Asp-Gly) to overcome the division limit in somatic cells. In a previous study, Khavinson et al., determine the ability Epithalon to induce expression of telomerase catalytic subunit, its enzymatic activity, and elongation of telomeres. They found that with the addition of Epithalon to aging cells in culture promoted the elongation of telomeres. Furthermore, the peptide treated cells underwent an additional 10 divisions (44 passages) when compared to the control, and continued to divide. Their results determined that Epithalon prolongs the cycle in normal human cells and overcomes the Heyflick Limit.

Khavinson, V.K., Bondarev, I.E., Butyugov, A.A. et al. Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. Bulletin of Experimental Biology and Medicine137, 503–506 (2004). https://doi.org/10.1023/B:BEBM.0000038164.49947.8c

Inhibiting effect of tumors

A study by Anisimov et al., 2002, found that female transgenic FVB mice with the breast cancer gene HER-2/neu that were injected monthly with Epithaon (1 μg subcutaneously for 5 consecutive days) starting from the 2nd month of life, decreased the probability of tumour growth to 3.7 times lower than in the control. Furthermore, the maximum size of breast adenocarcinomas was 33% lower than in the control (p<0.05). This shows that by supressing the HER-2/neu gene expression, Epithalon inhibits breast tumor growth in female trangenic FVB mice.

Anisimov, V.N., Khavinsov, V.K., Alimova, I.N. et al. Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging. Bulletin of Experimental Biology and Medicine133, 167–170 (2002). https://doi.org/10.1023/A:1015555023692

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