Updated: Mar 29, 2022
Introduction to RAD140
RAD-140, or Testolone, is a Selective Androgen Receptor Modulator (SARM) which was first developed by Radius Health, Inc., it was originally developed as a substitution for exogenous Testosterone. It has been researched as a treatment for muscle wasting and osteoporosis. It has been shown to suppress the growth of breast cancer that are positive for both androgen and estrogen receptors. The first-in-human study was initiated in 2017 in patients with breast cancer. It was licensed to Ellipses Pharmaceuticals in 2020. RAD 140 is still in the first stage of clinical trials with the results expected in late 2020. When released these trials will share the safety, toxicity and potential adverse effects of RAD 140. In Animal studies, RAD-140 has been found to be a safer alternative to testosterone (TRT therapy) in rats. In 2011 a study found RAD-140 to increase lean muscle mass in primates.
RAD140 (Testolone) mimics testosterone but targets muscles and minimally affects other organs (e.g. prostate). Benefits include increased muscle mass, increased fat-burning, beneficial in breast cancer treatment, and neuro-protecting. Adverse effects include testosterone supression and associated problems (hair-loss, fatigue, mood-swings).
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Mechanism of Action of RAD140
RAD-140 selectively stimulates androgen receptors in the body, targeting receptors in the muscle and bones while minimizing effect on reproductive organs. Testolone stimulates muscle growth by promoting the developement of new muscle cells and proteins.
Side Effects RAD140
Testolone structure is different from the structure of steroids, thus pathways that convert testosterone into estrogen cannot act on RAD-140. This suggests RAD-140 cannot convert to estrogen. However, suppression side effects may exist at dose-dependent levels these include:
Breast tenderness/growth in men, Abnormal body hair growth in women, Changes in sex drive, Male pattern baldness/hair loss, Mood swings and anxiety/depression, Nausea and vomiting. It may slightly raise blood estradiol.
In theory and in practice, RAD140 can potentially cause testosterone suppression and estrogen buildup. This can cause decreased sex drive, depression, and fatigue. Users recommend PCT (Clomid or Nolvadex) to restore hormone levels.
The degree of suppression or estrogen-like effects can vary – some users report being more sensitive to it, while it doesn’t impact others as much. Greater doses and longer use of any substances will always increase your risk of unwanted effects.
In a study conducted on rats, RAD140 showed potential to activate receptors in injured regions of the brain. In test subjects administered with RAD-140 MAPK activity increased protecting neurons in the brain.
Another study administered varied doses of RAD-140 to 9 different monkeys and observed an increase in lean muscle mass after 28 days.
There is no set dose for RAD140, as it hasn‘t been investigated in humans.
Bodybuilding resources recommend a dosage of 10 mg per day for men and 5 mg per day for women, cyc,led for 8-12 weeks.
These doses are purely speculative and not backed up by scientific research.
RAD140 appears to have good bioavailability. According to research in monkeys, about 70% of the drug is absorbed into the body when ingested.
Post-Cycle Therapy RAD140
The use of RAD-140 can suppress the body’s ability to produce testosterone. User's recommend PCT after RAD-140 (Nolvadex and Clomid) to restore hormone levels.
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